2-natural transformation?
The notion of 2-topos is the generalization of the notion of topos from category theory to the higher category theory of 2-categories.
There are multiple conceivable such generalizations, depending in particular on whether one tries to generalize the notion of Grothendieck topos or of elementary topos, and in the latter case what axioms one chooses to take as the basis for generalization.
In contrast, (2,1)-toposes are much better understood.
A Grothendieck 2-topos is a 2-category of 2-sheaves over a 2-site.
A Grothendieck (2,1)-topos is a (2,1)-category of (2,1)-sheaves over a (2,1)-site.
See also higher topos theory.
The archetypical 2-topos is Cat.
2-topos
Ross Street, Characterization of Bicategories of Stacks Category theory (Gummersbach 1981) LNM 962, 1982, MR0682967 (84d:18006)
Mark Weber, Yoneda structures from 2-toposes (pdf)