Supercompact cardinals are among the large cardinals.
By invoking Vopěnka's principle one can make strong statements about the existence of reflective subcategories. The assumption of supercompact cardinals is much weaker, and accordingly they similarly imply existence of reflective subcategories only under some more additional assumptions. The following theorems are all from (BCMR).
Suppose there are arbitrarily large supercompact cardinals. Then if is a reflection on an accessible category and the class of -equivalences is -definable, then the -local objects are a small-orthogonality class (so that is a localization with respect to some set of morphisms).
Suppose there are arbitrarily large supercompact cardinals. Then any full subcategory of a locally presentable category which is closed under limits and -definable is reflective.
Supercompact cardinals are discussed for instance in
T. Jech Set Theory The Third Millenium Edition, Revised and Expanded. Springer Monographs in Mathematics. Springer-Verlag, Berlin, Heidelberg (2003)
A. Kanamori, The Higher Infinite: Large Cardinals in Set Theory from Their Beginnings Perspectives in Mathematical Logic. Springer-Verlag, Berlin, Heidelberg (1994)
The relation to refelctive subcategories is discusssed in